KEGG pathway analysis showed that miR-206 and miR-378d and their target genes were associated with proteoglycans in cancer, endocrine resistance, AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt signaling pathway, hepatocellular carcinoma, renal cell carcinoma, cellular senescence, AMPK and MAPK signaling pathways, and GnRH secretion (Figure 3E). This evidence concerns the gene AKT1 and hereditary clear cell renal cell carcinoma.