KEGG pathway analysis suggested that the target genes of miR-139-5p and miR-374b-5p were associated with: EGFR tyrosine kinase inhibitor resistance, Focal adhesion, Gastric cancer, Hepatocellular carcinoma, Renal cell carcinoma, Rap1 signaling pathway, Ras signaling pathway, Breast cancer, and Human papillomavirus infection. The gene discussed is EGFR; the disease is hepatocellular carcinoma.