AKT1 and renal cell carcinoma: KEGG pathway analysis showed that miR-206 and miR-378d and their target genes were associated with proteoglycans in cancer, endocrine resistance, AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt signaling pathway, hepatocellular carcinoma, renal cell carcinoma, cellular senescence, AMPK and MAPK signaling pathways, and GnRH secretion (Figure 3E).