In ECs, the KEGG pathway analysis suggested the target genes of multiple miRNAs to be associated with: PI3K-Akt signaling, microRNAs in cancer, pancreatic cancer, prostate cancer, hepatitis C, melanoma, glioma, measles, breast cancer, cellular senescence, p53 signaling, lipid and atherosclerosis, Th1 and Th2 cell differentiation, Th17 cell differentiation, and adherens junctions (Figure 3F). This evidence concerns the gene AKT1 and melanoma.