CD28 and cancer: Reactome analysis identified transcriptional regulation of pluripotent stem cells, signaling by activin, Chk1/Chk2(Cds1)-mediated inactivation of Cyclin B:Cdk1, Polo-like kinase-mediated events, synthesis, secretion, and deacylation of Ghrelin, diseases of signal transduction, CD28 dependent PI3K/Akt signaling, constitutive signaling by AKT1 E17K in cancer, VEGFR2-mediated vascular permeability, and CD28 co-stimulation, were the top 10 processes associated with miR-206, miR-99a-5p, and miR-128-3p.