Furthermore, WikiPathways analysis suggested that the target genes of multiple miRNAs in EVs were associated with non-small cell lung cancer, hepatitis C and hepatocellular carcinoma, bladder cancer, RAC1/PAK1/p38/MMP2 pathway, aryl hydrocarbon receptor, signaling pathways in glioblastoma, pancreatic adenocarcinoma, breast cancer pathway, DNA damage response, miRNA regulation of DNA damage response, as well as IL-6 signaling and cytokines and inflammatory response. The gene discussed is RAC1; the disease is hepatocellular carcinoma.