Moreover, the Reactome analysis suggested that the target genes of multiple miRNAs are associated with cellular senescence, MAPK family signaling cascades, oncogene-induced senescence, constitutive signaling by EGFRvIII, signaling by EGFRvIII in cancer, as well as VEGFA-VEGFR2 pathway, interleukin-4 and 13 signaling, interleukin-6 family signaling, TCR signaling, and TNFR1-induced NF-kB signaling pathway. Here, IL4 is linked to cancer.