KEGG pathway analysis identified the target genes of multiple miRNAs in EVs to be associated with: microRNAs in cancer, human cytomegalovirus infection, Hepatitis C, bladder cancer, non-small-cell lung cancer, proteoglycans in cancer, cellular senescence, melanoma, glioma, and chronic myeloid leukemia, JAK-STAT signaling, p53 signaling, EGFR tyrosine kinase inhibitor resistance, IL-17 signaling pathway, inflammatory bowel disease, Th17 cell differentiation, and cytokine–cytokine receptor interaction (Figure 3E). This evidence concerns the gene EGFR and melanoma.