Furthermore, disease ontology revealed that target genes of miR-128-3p were significantly associated with neuroblastoma (DCX, RELN, EGFR, BMI1, SIRT1, KLF4, VEGFC, PTEN, SNAI2, BAX, RET, MTOR, IGF1, PIK3R1) peripheral vascular disease, Alzheimer’s disease, dementia (RELN, SREBF1, SREBF2, ABCA1, BAX, IGF1), atherosclerosis, arteriosclerotic cardiovascular disease, arteriosclerosis, brain disease, motor neuron disease, malignant glioma, myocardial infarction, congestive heart failure, congenital heart disease, and coronary artery disease (Supplemental Table S3). Here, SIRT1 is linked to early-onset autosomal dominant Alzheimer disease.