In ECs, the WikiPathways analysis suggested that the target genes of multiple miRNAs were associated with signaling pathways in glioblastoma, PI3K-Akt signaling pathway, pancreatic adenocarcinoma pathway, focal adhesion, integrated breast cancer pathway as well as interleukin-11 signaling pathway, extracellular vesicle-mediated signaling in recipient cells, VEGFA-VEGFR2, hypothesized pathways in the pathogenesis of cardiovascular disease, signaling pathway and brain-derived neurotrophic factor (BDNF) signaling pathway. The gene discussed is AKT1; the disease is glioblastoma.