Genetic work up came negative for C3; complement factor B (CFB); complement factor H (CFH); complement factor H-related protein 1; complement factor I, II, and V (CFI); complement regulatory protein CD46; thrombomodulin gene (THBD); complement receptor 1 (CR1); protectin (CD59); diacylglycerol kinase e (DGKE); inverted formin 2 (INF-2); methylmalonic aciduria cobalamin deficiency) chic type with homocystinuria (MMACHC); methylmalonyl-coa mutase (MMUT); phosphatidylinositol glycan biosynthesis class A protein (PIGA); and plasminogen (PLG). This evidence concerns the gene PLG and Methylmalonic aciduria.