The agglutinin-like sequence (ALS) family protein consists of eight discovered genes that encode large glycosylphosphatidylinositol (GPI)-linked glycoproteins on the cell surface and is well known to play an important role in adhesion to the host cells in C. albicans [23] and Saccharomyces cerevisiae [24], which is vital for pathogenesis as adhesion toward human epithelial cells can significantly increase the risk of invasive Candidiasis. This evidence concerns the gene ART4 and candidiasis.