Notably, autologous vaccination with TriMix-DCs thawed with melanoma-associated antigens (MAGE-A3, MAGE-C2, tyrosinase, gp100) has been shown to induce expansion of vaccinal neoantigen-directed T lymphocytes, found present both in peripheral blood samples in 11/14 and in skin biopsies in 12/14 of evaluable treated patients [44]. Here, TYR is linked to melanoma.