TG4001 (Transgene, Illkirch-Graffenstaden, France) (also known as tipapkinogene sovacivec) is a non-propagative, highly attenuated vaccinia vector (MVA) which is engineered to express the coding sequences of the HPV16 E6 and E7 tumor-associated antigens and the cytokine, IL-2. The gene discussed is IL2; the disease is neoplasm.