KRAS and infection: Huh-7.5 cells, which are permissive for WT DTV infection, were infected at a low MOI (0.01 PFU/cell) with WT DTV and DTV controls (R1_CDLR and R2_CDLR), which contain identical dinucleotide frequencies, scrambled within region 1 (NS1 to NS3-encoding) or region 2 (NS3-encoding) to assess whether important secondary RNA structures reside in those regions, which would preclude their use for recoding.