The IBD patients treated with anti-TNFα agents showed an IFNγ geometric mean value after SARS-CoV-2 Ag1 stimulation of 0.11 IU/mL [0.04–0.18], compared to 0.13 IU/mL [0.06–0.2] the non-biological regimen group. Here, IFNG is linked to inflammatory bowel disease.