Furthermore, they revealed that miR-34a-5p was significantly upregulated in the tumor tissues upon Luteolin treatment, and mouse double minute 4 (MDM4), a potential oncogene responsible for the repression of p53 transcription and induction of its proteasomal degradation, was found to be a direct target of MDM4, as the Luteolin treatment was associated with increased p53 and p21 and decreased MDM4 expressions both in vitro and in vivo. The gene discussed is TP53; the disease is neoplasm.