ESR1 and breast carcinoma: For instance, in earlier studies, Sato et al., 2015, demonstrated that Luteolin was able to decrease the cytotoxicity induced in the MCF-7 cells by Doxorubicin and even caused the attenuation of the Doxorubicin-induced cytotoxicity in the presence of ER antagonist and the ER-negative MDA-MB-453 human breast cancer cells.