The combination also reduced the phosphorylation of Akt and ERK1/2 in BT474 human breast cancer cells, suggesting that a combination of Luteolin and Lapatinib synergistically inhibited the growth of breast cancer cells, possibly by inducing apoptosis via the deactivation of Akt and ERK signaling cascades [137]. This evidence concerns the gene MAPK3 and breast carcinoma.