CASP8 and non-small cell lung carcinoma: From this perspective, in their study, Cho et al., 2015, investigated the radiosensitizing activity of Luteolin in NSCLC and revealed that in NCI-H460 and NCI-H1299, NSCLC cells, co-treatment of Luteolin and ionizing radiation promoted apoptosis by downregulating Bcl-2 and activating Caspase-3, Caspase-8, and Caspase-9; it also caused induction of phosphorylation of p38 MAPK and reactive oxygen species (ROS) accumulation [66].