Finally, Yao et al., 2019, in their study, aimed to investigate the roles of micro RNAs (miRNAs) in treating CRC cells with Luteolin and found that Luteolin inhibits the migration and invasion of the CRC cells by regulating the miR-384/pleiotrophin axis, suggesting that miR-384 and pleiotrophin can be important targets for treating CRC [55]. This evidence concerns the gene PTN and colorectal carcinoma.