PARP1 and gastric cancer: Furthermore, Luteolin caused inhibition of proliferation and invasiveness and promoted apoptosis of c-Met overexpressing gastric cancer cell lines, MKN45 and SGC7901; further studies indicated that Luteolin enhanced the activation of proteins related to apoptosis, such as Caspase-3 and poly (ADP-ribose) polymerase-1 (PARP-1), and caused downregulation of invasion-related protein MMP-9 [88].