Their study revealed that Luteolin, Ellagic Acid, and Punicic Acid inhibited growth and metastasis in the C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) axis in human prostate cancer xenograft tumors in severe combined immunodeficiency mice [82]. This evidence concerns the gene CXCL12 and Familial prostate cancer.