NFE2L2 and malignant colon neoplasm: The study revealed that Luteolin demonstrated its anticancer effects on HT-29 and SNU-407 colon cancer cell lines by promoting apoptosis, increasing the Nrf2 transcription that is influenced by the enhancement in the DNA methylation of Nrf2 promoter, and by causing an increment in the interaction between Nrf2 and p53.