Moreover, Luteolin has been shown to induce apoptosis through activation of the mitochondria-mediated caspase pathway in HT-29 colon cancer cell line and caused loss of the mitochondrial membrane action potential, enhanced levels of mitochondrial calcium (Ca2+), increased Bcl-2-associated X protein (Bax) and decreased B-cell lymphoma 2 (Bcl-2) expressions, and caused an increment in the active Caspase-9 and Caspase-3 levels [47]. Here, CASP3 is linked to malignant colon neoplasm.