The study revealed that Luteolin suppressed the growth of lung cancer cells, metastasis, and Notch-1 signaling pathway by regulating the circ_0000190/miR-130a-3p axis in vitro and by regulating circ_0000190, Luteolin suppressed the tumor growth of lung cancer in vivo [75]. This evidence concerns the gene NOTCH1 and lung carcinoma.