In contrast, in the study by Lee and Kwon, 2019, Luteolin was demonstrated to induce autophagy only in the p53-null Hep3B hepatocellular carcinoma cells and discovered that Luteolin-induced autophagy inhibited the reduction in cell numbers when co-incubated with the autophagy inhibitor, meaning that autophagy induced by Luteolin in Hep3B cells resulted in the enhancement of cell viability instead of cytotoxic effects [116]. Here, TP53 is linked to hepatocellular carcinoma.