AKT1 and glioblastoma: In their study, Anson et al., 2018 showed that Luteolin significantly decreased the proliferation of glioblastoma cells in vitro in the presence or absence of EGF, wherein Luteolin caused a decrement in the expression levels of phosphorylated Akt, mTOR, p70S6K, and MAPK in the presence of EGF.