Furthermore, they revealed that miR-34a-5p was significantly upregulated in the tumor tissues upon Luteolin treatment, and mouse double minute 4 (MDM4), a potential oncogene responsible for the repression of p53 transcription and induction of its proteasomal degradation, was found to be a direct target of MDM4, as the Luteolin treatment was associated with increased p53 and p21 and decreased MDM4 expressions both in vitro and in vivo. Here, MDM4 is linked to neoplasm.