In a study by Jiang et al. 2021, the effect and the underlying mechanism of Luteolin, Apigenin, and the anti-PD-1 antibody combined with either Luteolin or Apigenin on the PD-L1 expression and anticancer properties were investigated in Kirsten rat sarcoma virus (K-Ras) mutant lung cancer [64]. Here, CD274 is linked to lung cancer.