TP53 and hepatocellular carcinoma: In the study by Cao et al., 2017, it was found that Luteolin reduced the viability of SMMC-7721 hepatocellular carcinoma cells that express wild-type p53 and caused significant cell cycle arrest at G0/G1 phase, resulting in the dramatic apoptosis induction, as proved by the increased Caspase-8 and decreased Bcl-2 expressions [115].