CASP3 and malignant colon neoplasm: In another study by Pandurangan and Ganapsam.,2013, Luteolin was shown to decrease the lysosomal enzymes’ activities and induce apoptosis by reducing the expression of antiapoptotic protein Bcl-2 while driving an increment in the pro-apoptotic protein Bax and Caspase-3 levels in AOM-induced colon cancer in aBalb/C mouse model [46].