They revealed that Luteolin inhibited tumor angiogenesis and cell proliferation in vivo by downregulating expressions of the lymphocyte function-associated antigen 3 (LFA-3), proliferating cell nuclear antigen (PCNA), and upregulating intracellular adhesion molecule 1 (ICAM-1) expression in tumor tissue [110]. The gene discussed is ICAM1; the disease is neoplasm.