CD4 and neoplasm: The PDAC TIME features were estimated and scored in three dimensions: stromal score (quantification of stromal components), immune score (quantification of infiltrative immune cells) and ESTIMATE score (overall quantification of tumor component purity) [50].By interpreting the CIBERSORTx outcomes, we discovered that the risk score was only positively correlated with the abundance of M0 macrophages and activated NK cells, while it was negatively correlated with the abundance of CD8+ T cells, CD4+ T cells, plasma cells and naive B cells.