TP53 and neoplasm: We found that DNAm AA in tumor tissue was negatively correlated with measures of tumor aggressiveness and genomic instability, including the presence of TP53 mutations (Fig. 4A), mutant-like TP53 functional status based on gene expression data (see Methods, Additional file 1: Figure S1) [15], higher tumor mutational burden (TMB, Fig. 4B), higher HRDetect score (a mutational signature-based score to predict homologous repair deficiency) (Fig. 4C), and increased percent genome influenced by somatic copy number alterations (PGS) (Fig. 4D).