Overall, the median DNAm AA was not significantly different between tumor and histological normal tissue (Fig. 2B); however, luminal A tumors exhibited increased DNAm AA (P = 0.004) while HER2-enriched/basal-like tumors exhibited markedly lower DNAm AA (P = < 0.0001) compared with paired normal tissue. The gene discussed is ERBB2; the disease is neoplasm.