Now, diagnostic GBM IDH wild-type diffuse astrocytic tumors in adults only retain one or more of the following three genetic parameters: mutations in the promoter of the TERT, epidermal growth factor receptor (EGFR) gene amplification (tumor-specific aberrations), or both gain of entire chromosome 7 and loss of the entire chromosome 10. The gene discussed is EGFR; the disease is glioblastoma.