Following fine mapping to identify the CCVs for BC, prioritizing loci with relatively few CCVs, chromatin conformation capture (3C) and luciferase assays have been performed at 16 BC risk loci implicating regulation of TERT [40], CCND1 [41], FGFR2 [42], IGFBP5 [43], MAP3K1 [44], ESR1, RMND1 and CCDC170 [45], KLF4 [46], NRBF2 [47], ABHD8 [48], FGF10 and MRPS30 [49], KLHDC7A, PIDD1, CITED4, PRKRIP1 and RASA4 [4], DUSP4 [27], NTN4 [50], TBX3 [35], and novel lncRNAs, CUPID1, and CUPID2 [51]. The gene discussed is KLF4; the disease is breast cancer.