CLDN1 and colorectal carcinoma: To explore our proposed KGs-guided new and repurposable candidate drugs for the treatment against CRC, we considered the proposed KGs based 11 key proteins (CXCL8, MMP7, CA4, ADH1C, GUCA2A, GUCA2B, CEMIP, ZG16, CLCA4, MS4A12 and CLDN1) and their regulatory 4 TFs proteins (FOXC1, YY1, GATA2 and NFKB1) as the drug target receptors and performed their docking simulation with 167 drug molecules collected from the DSigDB database and published articles (Fig. 9A).