To explore candidate drugs for CRC, we considered 11 KGs based proteins (CXCL8, MMP7, CA4, ADH1C, GUCA2A, GUCA2B, CEMIP, ZG16, CLCA4, MS4A12 and CLDN1) and its regulatory key 4 TFs proteins (FOXC1, YY1, GATA2 and NFKB1) as the m = 15 drug target receptors. Here, CLDN1 is linked to colorectal carcinoma.