The abnormally expressed peptide hormones GUCA2A and GUCA2B play as paracrine endogenous ligands for the guanylate cyclase-C (GUCY2C) receptor and help for the development of tumors in CRC by the association comparatively in lower levels with the disrupted intestinal homeostasis [115]. The gene discussed is GUCA2B; the disease is colorectal carcinoma.