TMED3 and Miyoshi myopathy: To investigate the clinical significance of TMED3 in MM, we analyzed the relationship between the expression patterns of TMED3 and the pathological parameters of patients, and observed that high TMED3 expression was associated with more distant lymphatic metastasis (P = 0.014) and higher pathological stage (P = 0.012) (Table 2), which was also verified by Spearman rank correlation analysis (Table 3).