FBXW7 and esophageal squamous cell carcinoma: To clarify the biological functions of the FBXW7 mutation in ESCC cells, CRISPR was used to knock out FBXW7, and a FBXW7 plasmid was used to rescue FBXW7 in FBXW7-KO cells (Fig. 2B and Supplementary Fig. 3B).