FBXW7 and esophageal squamous cell carcinoma: We found that the proliferation of ESCC cells increased after FBXW7 knockout (gFBXW7-1 and gFBXW7-2) but decreased in FBXW7 recovered after overexpression of FBXW7 in gFBXW7-1 cells (FBXW7-RE, Fig. 2C).