FBXW7 and esophageal cancer: Firstly, we detected the expression of FBXW7 in six esophageal cancer cell lines by Western blot and found that FBXW7 presented strong expression in less malignant cell lines such as KYSE70 and KYSE180, but lower in the higher malignant KYSE30, KYSE150 and KYSE510 (Fig. 2A and Supplementary Fig. 3A).