In addition, we verified the downregulation of miR-126 in periodontitis by RNAScope (Fig. 2E and S3) with the same batch of samples as shown in Fig. 2A. When compared with the healthy tissues, miR-126 expression was significantly decreased in CD68 positive macrophages in periodontitis samples, as shown in the double-stained images (Fig. 2F and S4). The gene discussed is CD68; the disease is periodontitis.