Among above miRNAs, we focused on these miRNAs that have been previously found to be involved in tumor chemo-resistance and AKT signal pathway, such as miR-221-3p, miR-185-5p, miR-138-5p, miR-21-3p, miR-222-3p, miR-7-5p, miR-885-5p, miR-485-5p, miR-22-3p and miR-511-3p. The gene discussed is AKT1; the disease is neoplasm.