Kidney Injury Molecule 1 (KIM1) for example has been shown in experimental models of kidney injury and human studies to be an intrinsic kidney injury marker whereas other markers such as Tumor Necrosis Factor Receptor 1 (TNFR1) represent filtration markers even in settings without intrinsic kidney damage [20, 21]. The gene discussed is TNFRSF1A; the disease is kidney injury.