APOB and Hypercholesterolemia: However, sequencing for these genes can only explain part of the patients [8] and most of studies have focused on some specific genes linked to familiar hypercholesterolemia, such as LDLR, APOB, and PCSK9, using gene panels instead of NGS, which may underestimate the proportion of monogenic dyslipidemia/hypercholesterolemia [9].