Since NEO-201 uses NK cells as one of the main effectors to kill its target cells through ADCC, we evaluated the relationship of soluble CEACAM-5, CEACAM-6 and MICA with the activation markers of NK cells from cancer patients enrolled in this study, and we measured the correlation between serum levels of soluble factors and response to treatment (PD or SD). This evidence concerns the gene CEACAM5 and cancer.