SOX17 and hepatocellular carcinoma: With regard to molecular profiling of YST, we previously observed high molecular similarities between YST and hepatocytes as well as hepatocellular carcinomas (HCC) regarding expression of endodermal factors like FOXA2, SOX17, APOA1 / A2 / B, ALB, FGA / B / G, and GATA3 / 4 / 6 (Ang et al. 2018; D’Amour et al. 2005; Wruck et al. 2021). Additionally, we found similarities in signaling pathway activities when comparing YST and HCC (enhanced WNT and BMP signalling) (Ang et al. 2018; D’Amour et al. 2005; Wruck et al. 2021).