Nevertheless, aberrant expression of FXR1 in spinal cord motoneurons of ALS patients [6], or sequestration of FMR1 in NCIs of TDP-43 or FUS [7], will most likely affect RNA editing, including possible consequences on synaptic transmission, neuromuscular junction integrity, and motoneuron survival. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.