CAMK2A and microcephaly: However, in this study, we constructed transgenic mice (Rosa26-LSL-IE2+/−, Camk2α-Cre), and we found that long-term HCMV-IE2 expression inhibits the proliferation and differentiation of neural stem cells, stimulates the activation of microglia and astrocytes in the nervous system, produces an inflammatory response, further leads to the death of neurons, disrupts the normal development of neural tissue, and ultimately leads to the occurrence of microcephaly.