These characteristics of low-titer anti-GAD Ab and CA show the following principle: “The presence of auto-Abs alone may not support the diagnosis of IMCAs due to multiple epitopes, while low-titer auto-Abs are not necessarily correlated with only low-level insults on the cerebellum.” This principle should be considered when diagnosing “not manifestly evident” autoimmunity. The gene discussed is GAD1; the disease is Autoimmunity.