In patients without prior cardiovascular disease, the estimates of the relative effect of thiazide or thiazide-like diuretics compared to ACE inhibitors on acute MI were similar to the original analyses—hazard ratios 0.90 (0.79 to 1.02; 95% CI), 0.52 (0.36 to 0.74; 95% CI), and 0.83 (0.65 to 1.05; 95% CI) in CCAE, MDCD, and MDCR respectively. The gene discussed is ACE; the disease is cardiovascular disorder.