For the five molecular indicators, including the ratio of p-GSK3β and GSK3β, the ratio of p-cPLA2 and cPLA2, cPLA2 and the levels of AA and PGE2, we found significant positive correlations between plasma of BD patients and plasma of CURD mice (0.5 < r < 1, p < 0.05, Supplementary Fig. 3a); similar correlations were also observed between plasma of MDD patients and plasma of CUMR mice (0.5 < r < 1, p < 0.05, Supplementary Fig. 3a). The gene discussed is GSK3B; the disease is major depressive disorder.