APOE and Cognitive impairment: Here, we study the modification effect of African and Amerindian ancestry-enriched genetic variants in the APOE region, on the effect of the APOE-ɛ4 alleles on MCI and MCI + , where MCI + defines a subset of the MCI group with suspected severe cognitive impairment, in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) population.