Since AR expression is specifically reduced in p130Cas-deficient GCTs, and mRNA levels of AR-regulated target genes specifically expressed in GCT cells, such as EGF, KLK1, Crips3, and Cftr, are reduced, GCT regression in p130CasΔepi– mice seemed to be due to the inhibition of AR signaling. The gene discussed is CFTR; the disease is granular cell tumor.