AKT1 and granular cell tumor: Our results also indicate that p130Cas plays an essential role in both androgen-dependent GCT development and progression of ER-Golgi network formation.p130Cas is involved in the modulation of cell proliferation, which is associated with the activation of Src kinase, extracellular signal-regulated kinase (ERK) 1/2, mitogen-activated protein kinase (MAPK), and Akt pathways35.