The N-glycan chain conformation of E-cadherin, a marker protein of epithelial cells and a transmembrane glycoprotein, greatly affects its adhesive properties [31], and in malignant tumors the N-glycan chains of E-cadherin tend to form a more complex branching chain structure [32], which promotes internalization of E-cadherin into the cytoplasm and disrupts intercellular adhesion, thereby disrupting the relevant signaling pathways and facilitating the occurrence of EMT [33]. This evidence concerns the gene CDH1 and cancer.