Sepsis: defined as one or more clinical symptoms suggestive of sepsis with a microbial isolate on blood culture; or a neonate with sterile blood culture with at least 2 sepsis screen markers being abnormal (absolute neutrophil count <1500/mm3; Total Leucocyte Count (TLC) <5000/mm3; immature to total neutrophil ratio >0.2; immature to total neutrophil ratio >0.2; C reactive protein (CRP) >1.2 mg/dL, ESR >15 mm). The gene discussed is CRP; the disease is Sepsis.