We measured circulating human cytokine levels in both tumor models and found that CAdVEC treatment induced expression of T helper 1 (TH1) [e.g., interferon-γ (IFN-γ)] and TH2 cytokines (e.g., IL-10), in addition to transgenic IL-12p70 (Fig. 2C). This evidence concerns the gene IFNG and neoplasm.