PPIB and cancer: Among the 17 human cyclophilins, CypA is the best studied.Theoverexpression of CypA is linked to the development of several typesof cancer.19,20 As a potential therapeutic target,CypA interacts with various drugs such as the immunosuppressive drugcyclosporine A and anti-cancer drugs, which have been shown to suppressthe rejection of organ transplants and reduce the overexpression ofCypA itself, respectively.