There have been proposed some clinical risk-scoring systems for predicting the IVIG-resistant cases based on the clinical data before IVIG treatment, such as Gunma (Kobayashi), Kurume (Egami), and Osaka (Sano) scorings, which were mainly based on pathologic examination, proteins, and other clinical indexes, such as the increased neutrophil count, the decreased platelet count, hyponatremia, hepatic dysfunction, and elevated C-reactive protein (CRP) [11–13]. The gene discussed is CRP; the disease is Hyponatremia.