To analyze whether ZIKV infection compromises the identity and/or function of differentiating/differentiated glial cells, we infected astrocytes-hNS1 at a MOI of 1, and compared the expression of the glial transcripts GFAP, SLC1A3 (encodes EEAT1), SLC1A2 (encodes EEAT2), GLUL (encodes GS), GRIN1 (encodes N-methyl-D-aspartate Subunit 1 Receptor, NMDARSubunit 1) and GJA1 (encodes connexin-43 (CX43)) at 5 dpi. Here, GFAP is linked to Zika virus infectious disease.