From the results of DisGeNET, the hub genes IL10, IL6, CXCL8, CSF2, IFNG, IL1B, and TNF were causing Visceral Leishmaniasis; IL10, IL4, CXCL8, IFNG, IL1B and TNF found to cause Cutaneous Leishmaniasis and Urban Cutaneous Leishmaniasis. This evidence concerns the gene IL1B and visceral leishmaniasis.