To interrogate the extent to which isoforms information adds to disease insight, we examined differences in abundances between healthy and early NSCLC subjects for BMP1 (Fig 2D–2G), C4A (S1 Fig), C1R (S2 Fig), and LDHB (S3 Fig) at the collapsed protein-level, NP:protein-level, and peptide-level. Here, C1R is linked to non-small cell lung carcinoma.