LMNA and Hutchinson-Gilford progeria syndrome: Children with Hutchinson-Gilford progeria syndrome (HGPS) have a mutation in the LMNA gene encoding lamin A/C, resulting in accumulation of an abnormal lamin protein called progerin; these patients age rapidly and die in their early to mid-teens from severe atherosclerosis (De Sandre-Giovannoli et al., 2003; Eriksson et al., 2003; Olive et al., 2010).