TET2 and acute myeloid leukemia: To better understand the role of mTET2 in development, we opted to express two mTET2 mutations in dTet expressing cells in Drosophila: the Arginine 43 to Glycine (R43G) mutation within the N-terminus of TET2 (previously found in a DIPG sample as part of a whole-exome sequencing study) and the Arginine 1261 to Cysteine (R1261C) mutation within the catalytic domain that is commonly found in AML patients [27] (Figure 1a, Supplemental Figure S1).