CYP1A1 and obesity due to melanocortin 4 receptor deficiency: As noted for WD-fed MR-Intact mice, WD also downregulated genes associated with extracellular matrix in SMC-MR-KO mice (Fig. 5C, Online Resources 26 and 27) and top upregulated genes also included those implicated in diabetes and obesity, such as Cd36, Txnip, Angptl4, Cyp1a1, and Fabp4 (Fig. 5D).