SMC-MR deletion alters non-myocyte gene signatures in mice fed control diet. Since bulk RNA sequencing analysis is largely dominated by cardiomyocyte mRNA, we next performed high-resolution scRNA-seq analysis of the non-myocyte cell populations to elucidate cell-specific changes elicited by WD feeding and potential mechanisms underlying protection via SMC-MR deletion in obesity. The gene discussed is NR3C2; the disease is obesity due to melanocortin 4 receptor deficiency.