NR3C2 and Wilson disease: Differential gene expression analysis did not reveal any genes/pathways altered as a result of SMC-MR-KO (compared to MR-Intact) in control chow-fed mice (Online Resource 10); however, key pathways that were identified using gene ontology (GO) enrichment analysis across other group comparisons included: water homeostasis (downregulated in WD-fed versus control-fed MR-Intact mice), circadian regulation (upregulated in WD-fed SMC-MR-KO WD versus WD-fed MR-Intact mice), and ketone metabolism (downregulated in WD-fed SMC-MR-KO versus WD-fed MR-Intact mice) (Online Resource 10).