As noted for WD-fed MR-Intact mice, WD also downregulated genes associated with extracellular matrix in SMC-MR-KO mice (Fig. 5C, Online Resources 26 and 27) and top upregulated genes also included those implicated in diabetes and obesity, such as Cd36, Txnip, Angptl4, Cyp1a1, and Fabp4 (Fig. 5D). Here, TXNIP is linked to obesity due to melanocortin 4 receptor deficiency.