Systemic MR blockade and SMC-specific MR deletion prevent WD-induced cardiac diastolic and coronary vascular dysfunction independent of blood pressure and adipose inflammation. WD feeding impaired cardiac diastolic function, indicated by increased LV filling pressure (E/E’), reduced septal wall motion in diastole (E’/A’), left atrial distension (LA/Ao), and induced cardiac hypertrophy in female mice (Fig. 1B, Online Resources 5-7). The gene discussed is NR3C2; the disease is cardiac hypertrophy.