In this regard, Sanfilippo and colleagues in 2017 confirmed that CHI3L1 is produced from activation of microglia and astrocytes during the progression of neurodegeneration in cortex and in the spinal cord of neurodegenerative diseases like MS, ALS, and Alzheimer’s disease [20]. The gene discussed is CHI3L1; the disease is early-onset autosomal dominant Alzheimer disease.