TBK1 and thyroid cancer: Silencing MAZ and TBK1 alone significantly inhibited the PI3K/Akt/mTOR pathway in thyroid cancer cells, whereas cotransfection with MAZ siRNA and TBK1 siRNA did not strengthen the inhibitory effect of MAZ RNA or TBK1 siRNA on the PI3K/Akt/mTOR pathway (Figure 6A,B).