When we utilized this anti‐LRP6/DKK1 combination approach and compared it to anti‐LRP6 alone in the myeloma setting (Fig. 5A), we saw that the combination approach (demonstrated by pink squares in Fig. 5B–D) more than doubled trabecular BV/TV in 5TGM1‐bearing mice (Fig. 5Bi, p < 0.0001). The gene discussed is DKK1; the disease is plasma cell myeloma.