Controversy exists surrounding the impact of enhanced Wnt signaling and overexpression of β‐catenin on tumor growth and survival in MM and other malignancies.(29, 30, 31) We utilized FACS analysis to examine whether enhanced Wnt signaling with anti‐LRP6 alone or the anti‐LRP6/DKK1 combination strategy exacerbates tumor burden. Here, LRP6 is linked to neoplasm.