We recently showed that genetic deletion of TFEB completely rescued renal cystogenesis and associated early lethality, as well as mTORC1 hyperactivation, in kidney‐specific Flcn KO mice (Flcnflox/flox; Ksp‐cre+), thus pointing at TFEB as a key driver of BHD associated kidney pathology (Napolitano et al, 2020). The gene discussed is TFEB; the disease is Birt-Hogg-Dube syndrome.