As evidenced by western blot results, the protein expression of cyclinD1 and CDK4 was appreciably reduced in tumor tissues following temozolomide treatment or the simultaneous treatment of temozolomide and si‐LINC00470, while there were reverse trends in mice treated with temozolomide + LV‐LINC00470 or temozolomide + LV‐SOX4 versus mice treated with temozolomide (Figure 4F). This evidence concerns the gene SOX4 and neoplasm.