CTLA4 and neoplasm: The PTT effect, as well as induced ICD, potentiated by the administration of CpG-PBNP-PTT and anti-CTLA-4 antibody (aCTLA-4) (at a concentration of 0.15 mg/mL of PBNPs, combined with irradiation by an 808 nm light at 0.75 W for 10 min and 20 μg/mL of aCTLA-4) in vitro in Neuro2a cells, stimulated the expression of antigens and molecular markers on the tumor cells; this, therefore, showed the potential to trigger immunostimulatory and immunosuppressive responses.