CD4 and neoplasm: The study reported an increase in cytokine levels as well as antitumor CD3+, CD3+CD4+ (Figure 3f), and CD3+CD8+ (Figure 3e) T cell proliferation while decreasing inhibitory immune CD25+CD4+ regulatory T cells (Tregs) (Figure 3g) and myeloid-derived suppressor cells (MDSCs) (Figure 3h), effectively changing the tumor microenvironment and inducing a strong antitumor immunity.