Authors further demonstrated, through the use of immunofluorescent staining of murine hepatic carcinoma cells (H22) treated with PCN-ACF-CpG@HA under light irradiation (670 nm, 0.1 W/cm2, 5 min), that ACF inhibits overexpression of survival/metastasis linked genes regulated by HIF-1α rather than inhibiting HIF-1α since it only blocks dimerization without affecting the expression. Here, HIF1A is linked to hepatocellular carcinoma.