CD274 and neoplasm: The cumulative effects of a systemic immune response culminated in a significant tumor-specific T cell activation, successfully suppressing local (98.3% TGI) and distant (94.4% TGI) tumors, completely curing two of the six mice treated (33.3% cure rate), and extending the median survival time from 23.5 (Cu-TBP and light treatment) to 31 days in combination treatment with α-PD-L1 [131].