CD4 and neoplasm: As a result, the combination of PDT-induced ICD and GEM immunosuppression inhibition improved DC maturation (from 5.48% to 11.6% in tumor-draining lymph nodes) and T-cell infiltration at the tumor site, as well as mobilizing a systemic body immunity (10.8% CD8+ T cells and 28.9% CD4+ T cells in the spleen), effectively inhibiting local tumor growth.