In a bilateral CT26 model, the combination of NaLnF4@MOF (8.4 mg/mL) PDT with α-PD-L1 (50 μg/mice) injection raised the amount of tumor-infiltrating CD45+ T cells, CD4+ T cells, CD8+ T cells, and NK cells in primary and distant tumors. This evidence concerns the gene CD4 and neoplasm.