The use of OIMH NPs in combination with α-PD-L1 (2.5 mg/kg) in a CT26 bilateral mice tumor model led to increased infiltration of CD4+ (18.9% and 33.4%) (Figure 7e,g) and CD8+ (36.7% and 35.1%) T cells (Figure 7f,h) in primary and distant tumors, respectively, resulting in greater tumor growth inhibition (Figure 7c,d). Here, CD4 is linked to neoplasm.