CD4 and neoplasm: When compared to the SP94-PB-SF-Cy5.5 NPs and NIR single treatment model (16.12 ± 1.37% and 11.00 ± 1.16%), the results showed an increase in CD3+CD8+ CTL (25.37 ± 2.66%) and CD3+CD4+ T helper (Th) (18.20 ± 0.87%) at the distant tumor.