INS and diabetes mellitus: In one study, 50 Sprague–Dawley rats (all male) with diabetes induced by the administration of streptozotocin were given 30 mg/kg of quercetin for 14 days; their elevated serum blood glucose and insulin decreased, together with their dyslipidemia, and oxidative stress and tissue injury biomarkers, and hyperlactatemia and ketoacidosis markers, which are complications of diabetes, all dramatically improving [81].