PTK2 and melanoma: In vitro: EGCG can inhibit the migration of B16-F3m cells as well as their invasion. Moreover, there is inhibition by the EGCG of the homotypic cell aggregation and also the activity of MMP-9 (matrix metalloproteinase-9) as well as the tyrosine phosphorylation of focal adhesion kinase (FAK).In vivo: EGCG can decrease lung metastases in mice bearing B16-F3m melanomas but it can increase the survival rate of melanoma-bearing mice.