In vitro: the treatment with curcumin can increase the tumor-suppressor genes tissue inhibitor metalloproteinase (TIMP-2) as well as the expression of E-cadherin and nonmetastatic gene 23 (Nm23).Moreover, this bioactive compound can contribute to the decrease of the binding of the treated cells to 4 extracellular matrix (ECM) proteins. Furthermore, there is a reduction of the binding to vitronectin, fibronectin, and collagen IV.Moreover, decrease in the expression of α5β1 and α (v) β3 integrin receptors.In vivo: the curcumin can contribute to the decrease of lung metastasis. The gene discussed is TIMP2; the disease is neoplasm.