Stem cell-derived exosomes (SC-Exos) attenuated neuronal apoptosis, augmented interferon-gamma (IFN-γ) and Bcl-2, and decreased IL-1α, IL-2, TNF-α, Bax, cytochrome C (CytC), and cleaved caspase-3 and caspase-9 production in rats with cerebral ischemia/reperfusion (I/R) injury. The gene discussed is IFNG; the disease is brain ischemia.