Hoshino et al. showed that in tumor metastasis, tumor cell-derived EVs were fused with organ-specific resident cells (fibroblasts, epithelial cells, etc.)to prepare the niche through exosomal integrins, which could lead to Src phosphorylation and proinflammatory S100 expression, facilitating tumor metastasis [65]. The gene discussed is SRC; the disease is neoplasm.